22+ Humoral Immunity B Cell Activation

The complement system of innate immunity is important in regulating humoral immunity largely through the complement receptor cr2 which forms a coreceptor on b cells during antigen induced activation.

Humoral immunity b cell activation. 2 do b cells and humoral immunity contribute to defense against intracellular pathogens. Display of antigen on fdcs is critical for clonal selection and affinity maturation of activated b cells. Humoral immune response is mediated by b cells. Based on the concept of division of labor by the cell mediated and the humoral arm of the immune response in controlling pathogens protection against intracellular microbes is generally thought to be mediated exclusively by cell mediated immunity this has led to the use of highly t cell centric. This section will focus on b cells and discuss their production and maturation receptors and mechanisms of activation. Activated t cell expresses cd40l interacts with cd40 on b cell which gives it a second signal b cell expresses receptors for cytokines secreted by t cell. B cells origin and maturation takes place in bone marrow.

Later on activation this b cell produces the same antibody. Differentiation and proliferation occur primary response needs signals from what to jump start b and t cell proliferation. Santosh yadav development of humoral immune response humoral immune response refers to the production of secreted antibodies by plasma cells following antigenic stimulation of b cells. Defect in humoral immunity leads to enhanced. Involves activation of b cells by antigen followed by their proliferation and differentiation in to plasma cells and memory cell. B cell production and maturation. However cr2 also retains antigens on follicular dendritic cells fdcs.

Each b cell has a unique surface receptor which is an antibody molecule. Humoral immunity can be transferred to other individuals by the transfer of serum antibodies. The humoral response in c57bl 6 mice was associated with differential activation of b cells and expansion of splenic cd21highcd23lowmarginal zone mz like b cells that coincided with parasite specific antibody secreting cell asc development in the spleen.